Genetic and hormonal influence on SARS-CoV-2-infection susceptibility

We read with interest the correspondence by Delanghe et al.,1 suggesting that genetic variants, and in particular Y chromosome polymorphisms, might explain outcome variations between genders. During the coronavirus disease 2019 (COVID-19) pandemic one prominent difference became apparent: men are more vulnerable to severe outcomes than women.2 We recently published an observational study putting forward the hypothesis that male hormones may explain the increased male susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.